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There are three main xanthine derivatives. Theophylline and aminophylline are methylxanthines once widely used for the treatment of asthma, but now less commonly so. Caffeine is a trimethylxanthine closely related to theophylline. And theobromine, which is a plant extract.
The exact mechanism of toxicity is not known.
Shannon M, Amitai Y, Lovejoy FH Jr. Multiple dose activated charcoal for theophylline poisoning in young infants. Pediatrics 1987;80(3):368-70 PMID3627887
Henderson A, Wright DM, Pond SM. Management of theophylline overdose patients in the intensive care unit. Anaesth Intensive Care 1992;20(1):56-62 PMID1609943