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wikitox:2.1.11.9.2.4_other_antidepressants [2018/09/01 09:00] (current)
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 +Link to [[:​wikitox:​problems_for_discussion_1_psychiatric_drugs|Problems for Discussion]]
 +
 +----
 +
 +====== Other antidepressants ======
 +
 +===== NEWER ANTIDEPRESSANT AGENTS =====
 +
 +After the introduction of the Serotonin Reuptake Inhibitors (SRIs), newer agents with a wider spectrum of action were developed in an attempt to match the efficacy of the Tricyclic Antidepressants and Monoamine Oxidase Inhibitors but with a better side effect and safety profile. As these drugs are relatively new it is not yet clear that these goals have been achieved.
 +
 +**Venlafaxine** and **nefazodone** are serotonin noradrenergic reuptake inhibitors (SNaRIs), **Mirtazapine** is a noradrenergic and specific serotonergic antidepressant (NaSSA) and **Reboxetine** is a noradrenaline reuptake inhibitor (NaRI).
 +
 +At low doses, where serotonin reuptake inhibition predominates **venlafaxine** is very similar in action to the SRIs; at higher doses, noradrenaline reuptake inhibition also occurs.
 +
 +**Nefazodone** inhibits the 5-HT2 receptor and this is thought to increase the binding of serotonin to the 5-HT1A receptor. Additionally,​ **nefazodone** causes weak inhibition of noradrenaline and serotonin reuptake.
 +
 +**Mirtazapine** inhibits α2-adreoreceptors,​ 5-HT2 and 5-HT3 receptors. These results in increased noradrenaline and serotonin release; the later having its main affect on 5-HT1A-mediated neurotransmission.
 +
 +**Reboxetine** it is a selective inhibitor of noradrenaline reuptake and has no serotonin effects.
 +
 +This group includes:
 +
 +  * [[:​wikitox:​2.1.11.9.2.4.1_bupropion|2.1.11.9.2.4.1 Bupropion]]
 +  * [[:​wikitox:​2.1.11.9.2.4.2_mirtazapine|2.1.11.9.2.4.2 Mirtazapine]]
 +  * [[:​wikitox:​2.1.11.9.2.4.3_mianserin|2.1.11.9.2.4.3 Mianserin]]
 +  * [[:​wikitox:​2.1.11.9.2.4.4_venlafaxine|2.1.11.9.2.4.4 Venlafaxine]]
 +
  
/home/wikitoxo/public_html/data/pages/wikitox/2.1.11.9.2.4_other_antidepressants.txt · Last modified: 2018/09/01 09:00 (external edit)