User Tools

Site Tools


WikiTox Home Page

Poisoning monographs

General background

Teaching outlines

Topic structure


Link to Problems for Discussion


This diverse group of drugs can be divided into the following groups:

  1. Direct acting vasodilators
    • Nitrates: Glyceryl trinitrate, Isosorbide Mononitrate, Isosorbide Dinitrate
    • Nitroprusside
    • Hydralazine
    • Diazoxide
    • Minoxidil
  2. Alpha Antagonists
    • Centrally acting: Clonidine (discussed separately), Methyl dopa
    • Peripheral Non-selective: Phentolamine, Phenoxybenzamine
    • Peripheral Selective: Prazosin, Terazosin
  3. Angiotensin acting
  4. Calcium Channel Blockers (discussed separately)


MacMillan AR, Warshawski FJ, Steinberg RA. Minoxidil overdose. Chest 1993;103(4):1290-1 PMID 8131492

Jahangiri M, Holdright DR. Myocardial infarction secondary to dipyridamole overdose. Arch Emerg Med 1992 Mar;9(1):62-4 PMID 1567532

Pigeon G, Genest J. Prolonged hydralazine hydrochloride administration in 132 hypertensive patients–Study of toxicity. Can Med Assoc J 1960 Oct 1;83:743-6 PMID 13735669

Varon J, Duncan SR. Naloxone reversal of hypotension due to captopril overdose. Ann Emerg Med 1991;20(10):1125-7 PMID 1928887

Farrell SE, Epstein SK. Overdose of rogaine extra strength for men topical minoxidil preparation. J Toxicol Clin Toxicol 1999;37(6):781-783 PMID 10584592

Rygnestad TK, Dale O. Self-poisoning with prazosin. Acta Med Scand 1983;213(2):157-8 PMID 6837333

Arora R, Timoney M, Melelli L. Acute Myocardial infarction after the use of sildenafil. N Eng J Med 1999;341(9):700 PMID 10475830

/home/wikitoxo/public_html/data/pages/wikitox/ · Last modified: 2018/09/01 09:00 (external edit)