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wikitox:2.2.5.2.2_ethylene_glycol

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wikitox:2.2.5.2.2_ethylene_glycol [2018/09/01 09:00]
127.0.0.1 external edit
wikitox:2.2.5.2.2_ethylene_glycol [2019/03/03 17:20] (current)
admin [Anion gap]
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 Metabolism of ethylene glycol and the formation of glycolic and lactic acids produces a raised anion gap metabolic acidosis. It is important to remember that patients who present early following ethylene glycol ingestion, prior to significant ethylene glycol metabolism, may have normal acid-base status and a normal anion gap. This situation signifies a good prognosis, as long as the diagnosis is made and appropriate treatment instituted to prevent the formation of toxic metabolites. Patients who present late following significant ethylene glycol ingestion are likely to have an established raised anion-gap metabolic acidosis. Metabolism of ethylene glycol and the formation of glycolic and lactic acids produces a raised anion gap metabolic acidosis. It is important to remember that patients who present early following ethylene glycol ingestion, prior to significant ethylene glycol metabolism, may have normal acid-base status and a normal anion gap. This situation signifies a good prognosis, as long as the diagnosis is made and appropriate treatment instituted to prevent the formation of toxic metabolites. Patients who present late following significant ethylene glycol ingestion are likely to have an established raised anion-gap metabolic acidosis.
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 +False elevations in lactate may be seen with some point of care analysis machines. In these machine glycolic acid and glyoxylic acid may cross-react with L-lactate oxidase used in blood gas analyzers lactate electrodes to induce false elevation of blood lactate. ([[https://​www.ncbi.nlm.nih.gov/​pubmed/​19041561|Pernet Am J Emerg Med 2009]])
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 ==== Osmolal gap ==== ==== Osmolal gap ====
wikitox/2.2.5.2.2_ethylene_glycol.txt ยท Last modified: 2019/03/03 17:20 by admin