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wikitox:2.2.5.2.2_ethylene_glycol

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wikitox:2.2.5.2.2_ethylene_glycol [2019/03/03 17:20]
admin [Anion gap]
wikitox:2.2.5.2.2_ethylene_glycol [2020/02/17 22:59] (current)
andrew [Serum ethylene glycol concentrations]
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   * g/L x 16.1 = mmol/L   * g/L x 16.1 = mmol/L
   * mmol/L x 0.062 = g/L   * mmol/L x 0.062 = g/L
- +  * **mmol/L x 6.2 mg/dL  (note most texts use mg/dL as the reporting units)** 
-A quantitative serum concentration of ethylene glycol may be useful to indicate the need for [[:​wikitox:​3.2.3.1.1_haemodialysis|haemodialysis]]. Availability of serum ethylene glycol concentrations is often an issue in suspected cases of ingestion, and often the diagnosis has to be made on the basis of history and collaborative biochemical evidence. A peak ethylene glycol concentration of > 50 mg/dL is associated with severe toxicity. A peak of less than 20 mg/dL is not associated with severe toxicity, but this concentration is only reassuring in a clinically well patient without a metabolic acidosis (a low ethylene glycol concentration may be measured in late presenters following metabolism of the parent molecule).+A quantitative serum concentration of ethylene glycol may be useful to indicate the need for [[:​wikitox:​3.2.3.1.1_haemodialysis|haemodialysis]]. Availability of serum ethylene glycol concentrations is often an issue in suspected cases of ingestion, and often the diagnosis has to be made on the basis of history and collaborative biochemical evidence. A peak ethylene glycol concentration of **> 50 mg/dL**  ​is associated with severe toxicity. A peak of less than 20 mg/dL is not associated with severe toxicity, but this concentration is only reassuring in a clinically well patient without a metabolic acidosis (a low ethylene glycol concentration may be measured in late presenters following metabolism of the parent molecule).
  
 See the following for lethal concentrations of alcohols and their corresponding osmolal gaps. See the following for lethal concentrations of alcohols and their corresponding osmolal gaps.
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 Osmolal gap=(Ethanol [mg/​dL])/​3.7 – 0.35 or, in SI units: \\ Osmolal gap (Osmol/​kg)=1.25 (Ethanol [mmol/L]) – 0.35 \\ (from [[http://​www.ncbi.nlm.nih.gov/​pubmed/​11719745|Purssell et al]]) Osmolal gap=(Ethanol [mg/​dL])/​3.7 – 0.35 or, in SI units: \\ Osmolal gap (Osmol/​kg)=1.25 (Ethanol [mmol/L]) – 0.35 \\ (from [[http://​www.ncbi.nlm.nih.gov/​pubmed/​11719745|Purssell et al]])
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 ==== Urinary oxalate crystals ==== ==== Urinary oxalate crystals ====
/home/wikitoxo/public_html/data/attic/wikitox/2.2.5.2.2_ethylene_glycol.1551651612.txt.gz · Last modified: 2019/03/03 17:20 by admin