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wikitox:3.2.1.1.1_acidosis [2018/09/01 09:00] (current)
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 +Link to [[:​wikitox:​3.2.1.1.1_acidosis_teaching_resources|3.2.1.1.1 Acidosis Teaching Resources]]
 +
 +----
 +
 +====== Acidosis ======
 +
 +There are only a few toxins that directly cause acidosis:
 +
 +  * [[:​wikitox:​2.1.11.5.1_acute_management_of_alcohol_problems|alcohol]]
 +  * [[:​wikitox:​2.2.5.2.5_methanol|methanol]]
 +  * paraldehyde
 +  * isoniazid (lactic acid)
 +  * [[:​wikitox:​2.2.5.2.2_ethylene_glycol|ethylene glycol]]
 +  * [[:​wikitox:​2.1.1.4_salicylates|salicylates]]
 +  * [[:​wikitox:​glyphosate|]]
 +
 +However
 +
 +  * renal failure (GFR < 10% of normal)
 +  * lactic acidosis
 +
 +may occur secondary to tissue hypoxia, shock or seizures from poisoning with many toxins including:
 +
 +  * [[:​wikitox:​3.2.1.1.9_differential_diagnosis_of_sympathomimetic_syndrome|Sympathomimetic drugs]]
 +  * [[:​wikitox:​2.2.9.1.1_carbon_monoxide|Carbon monoxide]]
 +  * [[:​wikitox:​2.1.11.9.2.1_tricyclic_antidepressants|Tricyclic antidepressants]]
 +  * Cellular poisons (e.g. [[:​wikitox:​2.1.1.5.1_colchicine|colchicine]],​ [[:​wikitox:​2.1.9.6_iron|iron]])
 +
 +Drug toxicity worsened by acidosis:
 +
 +  * Tricyclic antidepressants
 +  * [[:​wikitox:​3.4.3.4_antiarrhythmics|Antiarrhythmic drugs]]
 +  * Quinidine
 +
 +Features that help to differentiate between these drugs are:
 +
 +  * [[:​wikitox:​level_of_consciousness|LEVEL OF CONSCIOUSNESS]]
 +  * [[:​wikitox:​myoclonic_jerking_or_hyperreflexia|HYPERREFLEXIA]]
 +  * [[:​wikitox:​heart_rates|HEART RATE]]
 +  * [[:​wikitox:​ecg_changes|ECG CHANGES]]
 +  * [[:​wikitox:​electrolytes_and_blood_glucose|ELECTROLYTES/​BLOOD GLUCOSE]]
 +  * [[:​wikitox:​osmolal_gap|OSMOLAL GAP]]
 +  * [[:​wikitox:​blood_concentrations|BLOOD CONCENTRATIONS]]
 +
  
/home/wikitoxo/public_html/data/pages/wikitox/3.2.1.1.1_acidosis.txt ยท Last modified: 2018/09/01 09:00 (external edit)