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wikitox:3.2.1.1.6_hypotension_and_bradycardia [2018/09/01 09:00] (current)
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 +====== Hypotension and Bradycardia ======
 +
 +**There are a relatively small number of toxins that commonly lead to hypotension and bradycardia. It is important to make a correct diagnosis, as these drugs are among the most lethal and have specific antidotes.**
 +
 +   * [[:​wikitox:​2.1.6.1.1_calcium_channel_blockers|Calcium channel blocking drugs (CCBs)]]
 +  * [[:​wikitox:​3.4.3.4.2_beta_blockers|Beta adrenoceptor blocking drugs]]
 +  * [[:​wikitox:​2.1.6.1.2_cardiac_glycosides|Digoxin]]
 +
 +In addition there are a number of toxins that will occasionally lead to bradycardia and hypotension in very severe poisoning but which usually cause either tachycardia or no change to heart rate.
 +
 +  * [[:​wikitox:​2.1.11.9.4_mood_stabilizers|Lithium]]
 +  * [[:​wikitox:​2.1.11.9.2.1_tricyclic_antidepressants|Tricyclic antidepressants (TCAs)]]
 +  * [[:​wikitox:​2.1.11.9.3_antipsychotics|Neuroleptics]]
 +  * [[:​wikitox:​2.1.11.2_anticonvulsants|Anticonvulsants]]
 +  * [[:​wikitox:​barbiturates|Barbiturates]]
 +  * [[:​wikitox:​chloroquine|Chloroquine]]
 +  * [[:​wikitox:​quinine|Quinine]]
 +  * [[:​wikitox:​2.1.1.3_opioids|Opioids]]
 +  * [[:​wikitox:​2.1.11.5.1_acute_management_of_alcohol_problems|Alcohol]]
 +  * [[:​wikitox:​2.2.7.4.5_organophosphates|Organophosphates]]
 +
 +Features that help to differentiate between these drugs are:
 +
 +  * [[:​wikitox:​response_to_painful_stimuli|RESPONSE TO PAINFUL STIMULI]]
 +  * [[:​wikitox:​pupil_size_and_reaction|PUPIL SIZE & REACTION]]
 +  * [[:​wikitox:​myoclonic_jerking_or_hyperreflexia|MYOCLONIC JERKING or HYPERREFLEXIA]]
 +  * [[:​wikitox:​bowel_sounds|BOWEL SOUNDS]]
 +  * [[:​wikitox:​ecg_changes|ECG CHANGES]]
 +  * [[:​wikitox:​response_to_antagonists|RESPONSE TO ANTAGONISTS]]
 +  * [[:​wikitox:​electrolytes_and_blood_glucose|ELECTROLYTES/​BLOOD GLUCOSE]]
 +  * [[:​wikitox:​blood_concentrations|BLOOD CONCENTRATIONS]]
 +
  
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