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wikitox:3.5.2_opioid_withdrawal

Opioid withdrawal

INTRODUCTION

Narcotic withdrawal is an unpleasant condition but is not medically dangerous or life threatening. This withdrawal syndrome has been greatly mythologised and is psychologically more frightening than the true clinical picture. Withdrawal symptoms are largely the reverse of the effects of the narcotic and require little medical intervention.

CLINICAL SYNDROME

Physical opioid withdrawal symptoms can be divided into minor and major categories:

Minor Major
Restlessness and irritabilityCramps
YawningAbdominal pain
Nasal dischargeDiarrhoea
LachrymationBack pain, pain in the long bones and muscle aches
“Goose flesh”
Dilated pupils
Perspiration
Insomnia
Nausea

ONSET OF WITHDRAWAL

Symptoms begin close to the expected time of the next dose. The severity of the withdrawal depends on the particular narcotic, total daily dose, interval between doses, duration of use, health and personality of user. The syndrome generally lasts for 5 - 7 days.

BEHAVIOURAL PROBLEMS

Some behaviours can become problematic with this group of patients but effective interpersonal relations can reduce or eliminate it. Drug seeking behaviour may include complaints, pleas, demands, manipulations and simulations of symptoms Manipulative behaviour may include manipulation of staff, family or other patients, playing one person against another, attempts to gain special attention or privileges and attention seeking behaviour. Passive-aggressive behaviour is a type of manipulative behaviour whereby a client does not express aggressive (angry, resentful, etc.) feelings directly, but denies them and reveals them instead indirectly through behaviour.

Nursing management of behavioural problems

  • Be consistent. This includes one staff member's interactions over time and also between staff members and between shifts
  • State the limits and the behaviour you expect from the patient - do not debate, argue, rationalise or bargain with the patient
  • Enforce all unit and hospital policies or regulations. Point out reasons for not bending the rules without apologising (be sure to examine your own feelings - do not react to the patient in anger or punitively)
  • Withdraw your attention from the patient if their behaviour is inappropriate (e.g.. If the patients says “you are the only staff member I can talk to…”). Confront the patient with the idea that this is not a good situation
  • Give attention and support when the patient exhibits appropriate behaviour) e.g. Discusses or expresses their feelings, e.g., anger, hurt or feelings of unworthiness). This encourages healthy and appropriate adult behaviour and interactions
  • Discuss the patient's behaviour with him/her in a nonjudgmental manner
  • Be kind but firm with the patient. Make it clear that the limits are set and maintained because you care for them and have their best interests at heart

DRUG TREATMENT

Clonidine

Treatment with clonidine may occur in an outpatient or inpatient setting. The aim of detoxification with the use of clonidine is to provide treatment which ill minimise any discomfort felt but also provide contact with a treatment agency or health facility which can provide support and ongoing help as required. The major adverse effects are sedation and hypotension

Dose
Treatment should be started at a dose which varies from 6 to 16 microg/kg/day in divided doses. The maximum dose is 16 micrograms per kilogram - which should only ever be given in hospital. The maximum dose as an outpatient should be 10 microg/kg. The treatment should continue for after 5-7 days and then always be “stepped down” over 2 days rather than stopped abruptly to avoid rebound hypertension. Do not start until the patient has gone 12 hours without using heroin.

Monitoring and suggested schedule
First dose

  • The BP is taken lying and standing
  • A test dose of 75 microg of clonidine is given orally
  • If the diastolic BP does not fall below 50 mm Hg give a further 75 microg dose
  • Choose the maintenance dose. The response to the test dose and the patients weight will provide a guide

Days 1 - 5

  • 150 microg - 300 microg clonidine is prescribed 8th hourly
  • Take BP immediately before and 30 minutes after each dose

Days 6 & 7

  • omit the midday or PM dose on day 6
  • check the BP before evening dose
  • reduce dose as convenient on day 7

In the first 48 hours of clonidine treatment, supplementary doses may be needed. Up to 450 microg extra can be given on Day 1 and up to 300 microg extra on Day 2. When giving supplementary doses only give 150 microg at a time and take BP at 5 and 30 minutes.

Other drugs used for treating withdrawal symptoms

  • Hyoscine may be used freely for abdominal cramps and diarrhoea. Non-opioid antidiarrhoeals can be used for diarrhoea
  • A benzodiazepine can be used at night on the first four nights
  • Narcotics and phenothiazines should not be used to treat heroin withdrawal if clonidine is being used

DIFFERENCES IN ACUTE TREATMENT OF THE OPIOID WITHDRAWAL SYNDROME

Heroin or other short acting opioids

Narcotic withdrawal is uncomfortable but not dangerous. Provide hyoscine, paracetamol or non-opioid antidiarrhoeals as appropriate, and refer to a specialist unit such as a drug treatment agency or methadone clinic for further assessment. DO NOT provide narcotics to a patients to “tide them over” between visits to a methadone clinic or similar. Methadone As methadone is so long acting there is no need to treat someone who has missed a dose for withdrawal. Similarly, people who claim to be traveling between one program and another will not need treatment. In any case, transfers between programs and “take away” arrangements for traveling are always arranged beforehand in considerable detail. Never give drugs to a methadone patient without contacting the prescriber or the Pharmaceutical Services Branch, or both.

Polysubstance use

The person managing the withdrawal must be aware that heroin users are often polydrug users and that the withdrawal syndrome may become complicated by another concurrent withdrawal state (e.g. benzodiazepine or barbiturate). Since withdrawal from these other drugs can be more serious and complicated by seizures, or in rare cases delirium, it is important to obtain as accurate a drug use history as possible. Urine drug screens should also be taken on admission. If another drug is involved specialist advice must be sought.

RESOURCES

wikitox/3.5.2_opioid_withdrawal.txt · Last modified: 2018/09/01 09:00 (external edit)