User Tools

Site Tools


wikitox:methaemoglobin

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

wikitox:methaemoglobin [2018/09/01 09:01]
127.0.0.1 external edit
wikitox:methaemoglobin [2020/05/31 23:50] (current)
andrew
Line 6: Line 6:
  
 ====== Methaemoglobin ====== ====== Methaemoglobin ======
- 
  
 ===== DEFINITION ===== ===== DEFINITION =====
Line 27: Line 26:
 4. Ascorbic acid and reduced glutathione can be used as electron donors to reduce oxidized iron.\\ 4. Ascorbic acid and reduced glutathione can be used as electron donors to reduce oxidized iron.\\
 a. These methods are much slower and quantitatively less important under normal circumstances. a. These methods are much slower and quantitatively less important under normal circumstances.
- 
  
 ===== PATHOPHYSIOLOGY ===== ===== PATHOPHYSIOLOGY =====
Line 76: Line 74:
 d. Primarily affect the cardiovascular system and CNS. d. Primarily affect the cardiovascular system and CNS.
  
-|**Methemoglobin Level** |**Signs and Symptoms***|+|**Methemoglobin Level** |**Signs and Symptoms***|
 |0 to 3%|Normal levels. No symptoms.| | |0 to 3%|Normal levels. No symptoms.| |
 |10 - 20%|Mild symptoms. Cyanosis. Chocolate-brown colored blood.| | |10 - 20%|Mild symptoms. Cyanosis. Chocolate-brown colored blood.| |
Line 130: Line 128:
 (a) Tachycardia or tachypnea\\ (a) Tachycardia or tachypnea\\
 (b) Metabolic acidosis\\ (b) Metabolic acidosis\\
-(c) End-organ dysfunction\\+© End-organ dysfunction\\
 (i) Altered mental status, seizures\\ (i) Altered mental status, seizures\\
 (ii) Dysrhythmias,​ myocardial ischaemia\\ (ii) Dysrhythmias,​ myocardial ischaemia\\
Line 150: Line 148:
 c. Hyperbaric oxygen.\\ c. Hyperbaric oxygen.\\
 i. Significantly increases the level of dissolved oxygen in the blood, thereby allowing for adequate oxygen delivery despite the absence of Hb. i. Significantly increases the level of dissolved oxygen in the blood, thereby allowing for adequate oxygen delivery despite the absence of Hb.
- 
  
 ===== TREATMENT FAILURE ===== ===== TREATMENT FAILURE =====
Line 178: Line 175:
 Rodriguez LF, Smolik LM, Zbehlik AJ: Benzocaine-induced methemoglobinaemia:​ report of a severe reaction and review of the literature. Ann Pharmacother 1994;​28:​643-649.\\ Rodriguez LF, Smolik LM, Zbehlik AJ: Benzocaine-induced methemoglobinaemia:​ report of a severe reaction and review of the literature. Ann Pharmacother 1994;​28:​643-649.\\
 Wright RO, Lewander WJ, Woolf AD. Methemoglobinaemia:​ Etiology, Pharmacology,​ and Clinical Management. Annals of Emergency Medicine 1999; 34 Wright RO, Lewander WJ, Woolf AD. Methemoglobinaemia:​ Etiology, Pharmacology,​ and Clinical Management. Annals of Emergency Medicine 1999; 34
 +
 +\\
  
  
/home/wikitoxo/public_html/data/pages/wikitox/methaemoglobin.txt · Last modified: 2020/05/31 23:50 by andrew