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wikitox:clonidine [2024/04/22 22:21] – kharriswikitox:clonidine [2025/02/17 00:28] (current) – kharris
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-Link to [[:wikitox:problems_for_discussion_2_clonidine|Problems for Discussion]]\\ +====== Centrally-acting Anti-hypertensives (α-adrenoceptor agonists) ======
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- <font 36px/inherit;;#c12b04;;inherit>Centrally-acting Anti-hypertensives (α-adrenoceptor agonists)</font> +
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 ===== Overview ===== ===== Overview =====
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 **CVS:** **CVS:**
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   * Early transient hypertension, secondary to peripheral α1-agnoist effect, is seen in up to a third of patients and can be severe in those with renal disease.   * Early transient hypertension, secondary to peripheral α1-agnoist effect, is seen in up to a third of patients and can be severe in those with renal disease.
   * Bradycardia is common (higher degrees of heart block can be seen but are rare) and sometimes associated with hypotension.   * Bradycardia is common (higher degrees of heart block can be seen but are rare) and sometimes associated with hypotension.
  
 **Other effects:** **Other effects:**
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   * Hypothermia   * Hypothermia
  
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 ===== Investigations ===== ===== Investigations =====
  
- \\ + \\ Besides the standard investigations, there are no specific laboratory tests that are useful in clonidine overdose. Normal urine toxicology screens are not useful for detecting clonidine.
-Besides the standard investigations, there are no specific laboratory tests that are useful in clonidine overdose. Normal urine toxicology screens are not useful for detecting clonidine.+
  
   * ECG – sinus bradycardia or heart block   * ECG – sinus bradycardia or heart block
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-===== References =====+===== Further Reading =====
  
   - Fiser DH, Moss MM, Walker W. Critical care for clonidine poisoning in toddlers. Crit Care Med 1990;18(10):1124–8. {{:wikitox:fisher-critical_care_for_clonidine_poisoning_in_toddlers.pdf|PDF}}   - Fiser DH, Moss MM, Walker W. Critical care for clonidine poisoning in toddlers. Crit Care Med 1990;18(10):1124–8. {{:wikitox:fisher-critical_care_for_clonidine_poisoning_in_toddlers.pdf|PDF}}