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| wikitox:methotrexate [2025/05/12 23:12] – [Decontamination] kharris | wikitox:methotrexate [2025/05/12 23:13] (current) – [Absorption] kharris | ||
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| ==== Absorption ==== | ==== Absorption ==== | ||
| - | Absorption of MTX after oral administration is saturable. MTX is absorbed from the gastrointestinal tract via the active transport system which is used for folates. The bioavailability falls with increasing doses from > 50% to < 25% of the ingested dose. At doses less than 30 mg/m2, absorption is 90% whilst at doses greater than 80 mg/m2, absorption is less than 20%. | + | Absorption of MTX after oral administration is saturable. MTX is absorbed from the gastrointestinal tract via the active transport system which is used for folates. The bioavailability falls with increasing doses from > 50% to < 25% of the ingested dose. At doses less than 30 mg/m< |
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| + | It is for this reason that high-dose MTX therapy must be administered parenterally to achieve the desired plasma concentrations. This saturable absorption may protect against toxicity following acute oral overdose. | ||
| - | It is for this reason that high-dose MTX therapy must be administered parenterally to achieve the desired plasma concentrations. This saturable absorption may protect against toxicity following acute oral overdose.\\ | ||
| ==== Distribution ==== | ==== Distribution ==== | ||