WikiTox

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== Seizures ======

===== SEIZURES and BRADYARRHYTHMIAS =====

The following drugs directly cause seizures (though so does hypotension).

  * [[:wikitox:3.4.3.4.2_beta_blockers|Propranolol and oxprenolol]]
  * [[:wikitox:2.1.11.9.2.1_tricyclic_antidepressants|Tricyclic antidepressants]]
  * [[:wikitox:2.1.11.9.3_antipsychotics|Antipsychotic drugs]] (particularly chlorpromazine and thioridazine)
  * [[:wikitox:2.1.11.2_anticonvulsants|Anticonvulsants]] (particularly [[:wikitox:barbiturates|]], carbamazepine and phenytoin)
  * [[:wikitox:2.1.1.3_opioids|Dextropropoxyphene]]
  * [[:wikitox:antimalarial_drugs|Antimalarial drugs]] (chloroquine, quinine)
  * [[:wikitox:3.4.3.4_antiarrhythmics|Antiarrhythmic drugs]]
  * [[:wikitox:2.1.11.4.1_anticholinergics|Orphenadrine]]
  * [[:wikitox:2.1.11.9.4_mood_stabilizers|Lithium]]

===== SEIZURES and TACHYARRHYTHMIAS =====

[[:wikitox:status_epilepticus_and_treatment_of_seizures|Seizures]] are commonly seen in severe poisonings with all the following drugs:

  * Tricyclic antidepressants
  * Anticonvulsants (particularly carbamazepine and phenytoin)
  * Antimalarial drugs (chloroquine, quinine)
  * [[:wikitox:3.4.3.4.2_beta_blockers|Beta blockers]] (particularly propranolol)
  * Antiarrhythmic drugs
  * Orphenadrine
  * [[:wikitox:2.1.11.9.4_mood_stabilizers|Lithium]]
  * Chloral hydrate
  * Adrenergic drugs ([[:wikitox:2.1.11.4.8.2_theophylline|theophylline]], [[:wikitox:2.1.11.4.8.1_cocaine|cocaine]] and amphetamines)
  * Drugs that lead to tissue hypoxia, acidosis or hypoglycaemia ( [[:wikitox:2.2.9.1.1_carbon_monoxide|CO]], [[:wikitox:2.2.7.4.4_organochlorines|organochlorines]], [[:wikitox:2.1.7.1.2_sulphonylureas|hypoglycaemic drugs]], [[:wikitox:2.1.7.1.1_insulin|insulin]], isoniazid, [[:wikitox:2.1.1.4_salicylates|salicylates]] etc.)