Link to [[:wikitox:3.2.1.1.1_acidosis_teaching_resources|3.2.1.1.1 Acidosis Teaching Resources]]

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====== Acidosis ======

There are only a few toxins that directly cause acidosis:

  * [[:wikitox:2.1.11.5.1_acute_management_of_alcohol_problems|alcohol]]
  * [[:wikitox:2.2.5.2.5_methanol|methanol]]
  * paraldehyde
  * isoniazid (lactic acid)
  * [[:wikitox:2.2.5.2.2_ethylene_glycol|ethylene glycol]]
  * [[:wikitox:2.1.1.4_salicylates|salicylates]]
  * [[:wikitox:glyphosate|]]

However

  * renal failure (GFR < 10% of normal)
  * lactic acidosis

may occur secondary to tissue hypoxia, shock or seizures from poisoning with many toxins including:

  * [[:wikitox:3.2.1.1.9_differential_diagnosis_of_sympathomimetic_syndrome|Sympathomimetic drugs]]
  * [[:wikitox:2.2.9.1.1_carbon_monoxide|Carbon monoxide]]
  * [[:wikitox:2.1.11.9.2.1_tricyclic_antidepressants|Tricyclic antidepressants]]
  * Cellular poisons (e.g. [[:wikitox:2.1.1.5.1_colchicine|colchicine]], [[:wikitox:2.1.9.6_iron|iron]])

Drug toxicity worsened by acidosis:

  * Tricyclic antidepressants
  * [[:wikitox:3.4.3.4_antiarrhythmics|Antiarrhythmic drugs]]
  * Quinidine

Features that help to differentiate between these drugs are:

  * [[:wikitox:level_of_consciousness|LEVEL OF CONSCIOUSNESS]]
  * [[:wikitox:myoclonic_jerking_or_hyperreflexia|HYPERREFLEXIA]]
  * [[:wikitox:heart_rates|HEART RATE]]
  * [[:concept_ecg_changes|ECG CHANGES]]
  * [[:wikitox:electrolytes_and_blood_glucose|ELECTROLYTES/BLOOD GLUCOSE]]
  * [[:wikitox:osmolal_gap|OSMOLAL GAP]]
  * [[:wikitox:blood_concentrations|BLOOD CONCENTRATIONS]]