Classification of Antiarrhythmic Drugs

Class Drugs Action
Ia Quinidine, Procainamide, Disopyramide Block fast sodium current. These also block repolarising potassium currents and hence lengthen action potential duration
Ib Lignocaine, Mexiletine, Phenytoin Block fast sodium current. This slows rate of depolarisation and reduces conduction velocity. These shorten action potential duration
Ic Flecainide, Encainide Block fast sodium current with slow offset kinetics. Cause marked depression of depolarisation with little change in action potential duration.
II Beta-Blockers Block effects of catecholamines
III Amiodarone, Sotalol Lengthen action potential duration by blocking potassium currents
IV Calcium channel blockers Block inward calcium current particularly notable in AV node
wikitox/3.4.3.4_antiarrhythmics.txt · Last modified: 2025/07/28 22:53