Virtually all patients should have an ECG on admission and many will require one later in the course of their admission. The primary purpose of an ECG is to identify cardiotoxic drug ingestion and to predict the development of complications. The most common significant abnormality is a prolonged QRS complex (greater than or equal to 100 ms (>= 2 1/2 little squares) in one or more limb leads.
In tricyclic antidepressant poisonings, this is predictive of complications of arrhythmias and seizures (Boehnert & Lovejoy, 1985). Conduction block, right axis deviation and prolongation of the QT interval may also be seen with many proarrhythmic drugs.
See also TCA poisoning
The most common drugs ingested that may show QRS and/or QT prolongation and arrhythmias (though these are not always present) are:
*These drugs are often referred to as having 'quinidine-like' effects, 'membrane-stabilising' properties or 'non-specific toxicity'
Carbon monoxide (CO) poisoning may be associated with ischaemic changes on the ECG.
For more mechanistic detail and clinical evaluation see Cardiotoxic drugs
QRS/QT prolongation suggests drugs with ion channel blocking effects. These will cause acidosis generally only if they lead to tissue hypoxia.
Heart block with a junctional rhythm suggests digoxin or calcium channel blocking drugs (CCBs).
Atrial fibrillation suggests digoxin and absence of P waves suggests CCBs.
Propranolol, sotalol, CCBs, TCAs, and neuroleptics commonly cause QRS or QT prolongation.
Third degree heart block will most commonly been seen with severe TCA poisoning, CCBs, propranolol or digoxin.
Ischaemic changes suggest amphetamine, cocaine, or other sympathomimetic drugs or drugs causing tissue hypoxia (e.g. CO).
QRS, QT prolongation suggests TCAs, antipsychotics or lithium.
Tachyarrhythmias occur with TCA poisoning but also with toxins leading to tissue hypoxia (e.g. CO).
Heart block suggests TCAs or propranolol.
Ischaemic changes may occur with any of these drugs in patients with underlying heart disease. In younger patients, their presence would suggest amphetamines or cocaine.
Preceding QRS & QT prolongation suggests drugs that blockade ion channels.
Ischaemic changes suggest drugs leading to tissue hypoxia.
Boehnert MT, Lovejoy FH, Jr. Value of the QRS duration versus the serum drug concentration in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N Engl J Med 1985; 313(8):474-479PMID4022081