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Poisoning monographs

General background

Teaching outlines

Topic structure

wikitox:module_2_antidiabetic_drugs_analgesics_nsaids_opioids_methotrexate_colchicine

Module 2 - Antidiabetic drugs, Analgesics and NSAIDs, Opioids, Methotrexate and Colchicine

OBJECTIVES

At the end of this module, students should be able to:
· Understand the mechanisms underlying the toxicity of these agents
· Undertake a risk assessment of poisoning
· Be aware of agents that have a delayed onset or protracted time course of poisoning and how patients should be monitored
· Understand the role and limitations of specific antidotes, where available
· Develop an approach for the treatment of these drugs, as single ingestants or co-ingestants.

BIGUANIDES, SULPHONYLUREAS AND INSULIN

Objectives

  • Understand the mechanism of toxicity and clinical effects including time course of hypoglycaemic agents
  • Understand the role of antidotes in hypoglycaemic poisoning
  • Understand some of the complexities in a medicolegal toxicology case

Reading

ANALGESICS AND ANTI-INFLAMMATORY NSAID POISONING

Paracetamol

Objectives

  • To be able to do a risk assessment of a paracetamol poisoning
    • Consider variables which may affect the risk assessment
  • Understand the limitations of the nomogram
  • Understand treatment of paracetamol poisoning
  • Discuss the effective methods of gastric decontamination in paracetamol overdose
  • Discuss the efficacy of available antidotes based on strength of evidence
  • Discuss the problems of management when working in resource poor settings
  • Compare the differences in prognosis and management in acute deliberate and accidental paracetamol overdose.

Reading

WikiTox Acetaminophen

See: Problems for Discussion

Anti-inflammatory NSAID

Objectives

  • Understand the mechanism of toxicity of NSAIDs.
  • Understand the potential complications of NSAID overdose in general and which agents have specific toxicities.

Reading

Analgesics and Anti-inflammatory NSAID Poisoning

See: Problems for Discussion

OPIOIDS

Reading

METHOTREXATE

Reading

COLCHICINE

Objectives

  • Understand the mechanism of toxicity
  • Be able to make a risk assessment
  • Understand the issues underlying the provision of antidotes

Reading

wikitox/module_2_antidiabetic_drugs_analgesics_nsaids_opioids_methotrexate_colchicine.txt · Last modified: 2018/09/01 09:01 (external edit)